CeMM-Pfizer Collaboration on Frangment based Compound Screening
Project Collaborators
- Fabian Offenspringer PhD
- Gary Tin PhD
- Miquel Duran-Frigola PhD
- Monica Schenone
- Georg Winter PhD
- Molecular Discovery Platform of CeMM
Ligandable Proteome
- Traditional drugs bind to hydrophobic pockets of Proteins
- Only ~20% of the Proteome is druggable with traditional approach
- Targeted Protein Degradation (TPD) overcomes inhibitor-centric approaches
- Molecular Glues - Chemically Induced Dimerization (CID) or Proximity-Inducing Pharmacology
- Targeted Protein Degradation (TPD)- Selected Protein made to bind with E3 ubiquitin ligase
Traditional Drugs vs TPD
Traditional Drugs vs TPD
Thank you!
Any questions?